Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing

Coalition Formation in a Legislative Voting Game

We experimentally investigate the Jackson-Moselle (2002) model where legislators bargain over policy proposals and the allocation of private goods. Key comparative static predictions of the model hold as policy proposals shift in the predicted direction with private goods, with the variance in policy outcomes increasing as well. Private goods increase total welfare even after accounting for their cost and help secure legislative compromise. Coalition formations are better characterized by an efficient equal split between coalition partners than the stationary subgame perfect equilibrium prediction

Structural Analysis and Matrix Interpetive System /SAMIS/ program Technical report, Feb. - Aug. 1966

Development of characteristic equations and error analysis for computer programs contained in structural analysis and matrix interpretive syste

Greenhouse screening for Fusarium wilt resistance in lupine

Fusarium wilt can cause total crop failure. Evaluation of Ffusarium resistance in heavily infected soil were performed in a grenhouse where the dominant fusarium species in the soil in descending order was F. oxysporum then F. avenaceum, F. culmorum, F. solani, F. gibbosum. Large fusarium wilt presure was observed and fully susceptible lines were completely destroyed by Fusarium wilt caused by F. oxisporum. Segregation in F2 and F3 in L. angustifolius showed that resistant genotypes have two dominant non-allelic resistance genes to wilt. We call this gene Relation to fusarium oxisporum (Rfo1,Rfo2). Susceptible genotypes have either two wild genes (++ ++) or one wild and one dominant resistant gene (++ Rfo2 Rfo2, or Rfo1Rfo1 ++). Crossing ‘++ Rfo2Rfo2’ to ‘Rfo1Rfo1 ++’ segregates in 9:7 resistant to susceptible in F2, respectively. The same segregation was observed by crossing ‘Rfo1Rfo1 Rfo2Rfo2’ to ‘++ ++’. We recommend the use of these resistant genes in breeding in areas with potential Fusarium wilt problems

Localization in orchards using Extended Kalman Filter for sensor-fusion - A FroboMind component

Making an automated vehicle navigate in rows of orchards is a feature, relevant for automating the plant nursing and cultivation of the trees. To be able to navigate accurate and reliably, the vehicle must know its position relative to the trees in the orchards

Quasiperiodic Solutions of the Fibre Optics Coupled Nonlinear Schr{\"o}dinger Equations

We consider travelling periodical and quasiperiodical waves in single mode fibres, with weak birefringence and under the action of cross-phase modulation. The problem is reduced to the ``1:2:1" integrable case of the two-particle quartic potential. A general approach for finding elliptic solutions is given. New solutions which are associated with two-gap Treibich-Verdier potentials are found. General quasiperiodic solutions are given in terms of two dimensional theta functions with explicit expressions for frequencies in terms of theta constants. The reduction of quasiperiodic solutions to elliptic functions is discussed.Comment: 24 page